Human adipocytes secrete mineralocorticoid-releasing factors
نویسندگان
چکیده
منابع مشابه
Adipocytes Secrete Leukotrienes
Leukotrienes (LTs) are potent proinflammatory mediators, and many important aspects of innate and adaptive immune responses are regulated by LTs. Key members of the LT synthesis pathway are overexpressed in adipose tissue (AT) during obesity, resulting in increased LT levels in this tissue. We observed that several mouse adipocyte cell lines and primary adipocytes from mice and humans both can ...
متن کاملEncapsulated pheochromocytoma cells secrete potent noncatecholamine factors.
Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines, including norepinephrine (NE). NE can have direct cardiomyocyte toxicity and/or can stimulate myocardial remodeling secondary to the induction of hypertension. Yet, the development of cardiomyopathy is not entirely related to catecholamine dose or the extent of hypertension. To explore these eff...
متن کاملHuman neutrophils secrete vascular endothelial growth factor.
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils released VEGF in response to different stimuli and we demonstrated by immunohisto...
متن کاملHuman Umbilical Vein Endothelial Cells Secrete Transcobalamin
Transcobalamin II (TC Ill is essential for cellular uptake of cobalamin. However, t h e origin of this t ransport protein is controversial and many organ sources have been suggested. We studied human umbilical vein endothelial cells cultured in vitro. The cells contained T C II (2.3 pmol/108 cells) and released progressively increasing amounts of t h e protein into t h e surrounding medium duri...
متن کاملHuman Platelets Secrete Chemotactic Activity for Eosinophils
Thrombin-stimulated platelets liberate factors that induce chemotaxis of eosinophils and raise their cytosolic Ca2+ content ([Ca2+],). The sources of this activity are the denseand a-granules because inhibition of prostaglandin endoperoxide/thromboxane A2 formation and the platelet-activating factor receptor-antagonist WEB 2086 have no effect. Platelets from patients with Storage-Pool Deficienc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2336140100